While compounds 289–291 did not show any inhibitory activity against the neurodegenerative disease kinase targets CDK5/p25, CK1δ, and GSK3β, 3-O-methyl massadine chloride (291) exhibited antibacterial activity against several Gram-positive and -negative bacteria with IC50 values below 5 μM [268]. Here, CDK5 is linked to neurodegenerative disease.