Only low cytotoxicities against human, bacterial, and fungal cell lines were observed, whereas the ningalins 183 and 184 showed moderate inhibition of the kinases CK1δ, CDK5, and GSK3β, potential targets for the treatment of neurodegenerative diseases (IC50 values between 1.6 μM and 10.9 μM) [174]. This evidence concerns the gene CDK5 and neurodegenerative disease.