However, other mechanisms may also be involved in slowing aging in vivo, including an increase in the activity of antioxidant enzymes, regulation of Klotho, inhibition of apoptosis, inhibition of matrix metalloproteins-1 (MMPs-1) expression, protection of mitochondrial activity by correct protein folding and decreased DNA mutation by the chaperonin containing t-complex polypeptide 1 and the phosphatase and tensin homolog (CCT-PTEN) Pathway, restoration of intestinal homeostasis and regulation of aging-related metabolic disorders. Here, PTEN is linked to metabolic disease.