Likewise, our previous study showed that dietary DHA-acylated AST diesters significantly attenuated cognitive disorders via decreasing the protein expression of Caspase 9, Caspase 3, and cleaved-Caspase 3 in the brain of mice with Alzheimer’s disease compared with unesterified AST [13]. The gene discussed is CASP3; the disease is early-onset autosomal dominant Alzheimer disease.