Both VWF levels and ADAMTS13 activity have been correlated in older patients with atrial fibrillation (AF) and an increasing stroke risk calculator scoring system, the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack/thromboembolism, vascular disease, age 65–74 years, female) [44]. The gene discussed is VWF; the disease is Stroke.