VWF and von Willebrand disease (hereditary or acquired): VWD can be classified as inherited, which can be further categorized into six different types (1, 2A, 2B, 2M, 2N, 3), and which results from a variety of mutations occurring throughout the VWF gene, or acquired, from a variety of conditions, including malignant disorders, aortic valve stenosis, or left ventricular assist devices [6,11,51,52].