SPTLC1 and type 2 diabetes mellitus: The inhibition was more potent for 1-deoxySA (IC50 2.6 μM) than for 1-deoxySOΔ14Z (IC50 4.8 μM) and in a similar concentration range as we find it in plasma of individuals with HSAN1 (0.6–2.5 μM) (55) or T2DM (0.3–0.9 μM) (21).