MAPK3 and fatty liver disease: Groups of Mttpf/f Villin Cre ERT2 (vehicle injected and control) and Mttp-IKO mice transitioned to a chow diet for 4 weeks showed a striking reduction in hepatic steatosis (Fig. 5A), with a greater reduction in Mttp-IKO mice (1,200 ± 153 → 294 ± 34 control vs. 102 ±15 μg/mg protein in Mttp-IKO), and a concomitant decrease in hepatic content of TG, cholesterol, and FFA (Fig. 5B).