In regard to the impact of impaired intestinal lipid transport on NAFLD, we and others have shown that mice with conditional intestinal deletion of microsomal triglyceride (TG) transfer protein (Mttp-IKO) demonstrate impaired chylomicron assembly and decreased intestinal fat (TG and cholesterol) absorption with decreased hepatic steatosis, despite increased hepatic de novo lipogenesis (DNL) and increased VLDL secretion (11, 12, 13). This evidence concerns the gene MTTP and fatty liver disease.