MTTP and Hepatic steatosis: In regard to the impact of impaired intestinal lipid transport on NAFLD, we and others have shown that mice with conditional intestinal deletion of microsomal triglyceride (TG) transfer protein (Mttp-IKO) demonstrate impaired chylomicron assembly and decreased intestinal fat (TG and cholesterol) absorption with decreased hepatic steatosis, despite increased hepatic de novo lipogenesis (DNL) and increased VLDL secretion (11, 12, 13).