Zhu et al. constructed a type 5 adenovirus recombined to carry the IL-24 gene (CNHK600-IL24) that replicates only in tumor cells; they established and treated a TNBC model in nude mice and a metastatic model of breast cancer, concluding that CNHK600-IL24 enhanced antitumor activity and improved survival in vivo [41]. The gene discussed is IL24; the disease is neoplasm.