HTRA1 and age-related macular degeneration: We did not have the power to investigate the effect of protective CFH-CFHR5 haplotypes on risk associated with loci other than ARMS2/HTRA1, but by showing that protection in the CFH-CFHR5 region alleviates risk in the two loci responsible for the majority of AMD, our study does indicate that targeting the complement system may have beneficial effects even when AMD is driven by other loci.