To elucidate why CFH Y402H, CFH I62V and the deletion of CFHR3/1 are a superior set of variants to describe common risk and protection against AMD, we performed a haplotype analysis of the CFH-CFHR5 locus using rs800892, rs1061170, rs140996, rs12144939 and rs61818925 (see Fig. 1c). The gene discussed is CFHR3; the disease is age-related macular degeneration.