Among the three genetic models grouped by study population, only adult MTHFR A1298C polymorphisms were found to be obviously correlated with stroke susceptibility (C vs A: OR = 1.18, 95%CI = 1.07–1.32, p = 0.002; CC + CA vs AA: OR = 1.19, 95%CI = 1.06–1.34, p = 0.008; CC vs CA + AA: OR = 1.48, 95%CI = 1.16–1.89, p = 0.002). The gene discussed is MTHFR; the disease is stroke disorder.