In ethnic subgroup analysis, MTHFR A1298C polymorphism was obviously correlated with increased risk of stroke under three genetic models of Asian population (C vs A: OR = 1.29, 95%CI = 1.16–1.44, p < 0.001; CC + CA vs AA: OR = 1.28, 95%CI = 1.17–1.47, p < 0.001; CC vs CA + AA: OR = 1.84, 95%CI = 1.49–2.27, p < 0.001). Here, MTHFR is linked to stroke disorder.