The SNP of CYP19 rs2414096 showed significant association with reduced aromatase activity, increased estradiol to testosterone ratio (E2/T), hyperandrogenic phenotype, and PCOS development in African, American, Caucasian [48], Chinese [49], Iranian [50], Indian [51], Iraqi [52], Egyptian [53]. The gene discussed is CYP19A1; the disease is polycystic ovary syndrome.