INS and polycystic ovary syndrome: In addition, some studies found a significant increase in insulin sensitivity (lower HOMA-IR), as well as lower fasting insulin and glucose levels in Caucasian population [90–93] and a lower hirsutism score in PCOS women carrying the Pro12Ala G allele [94]; however, others, found no link between fasting glucose and insulin or changes in HOMA-IR in PCOS women carrying the Pro12Ala G allele [240–243].