We used transgenic Tg (Thy1-APPSw,Thy1-PSEN1*L166P) 21Jckr, also called APP/PS1-21 mice [39] crossed with immunodeficient NOD.CB17-Prkdcscid/J, further called NOD-SCID mice [40], to generate AD mice or wild-type (WT) littermates suitable for grafting experiments [31]. The gene discussed is PSEN1; the disease is Alzheimer disease.