BRCA1 and complete blood cell count: Previous meta-analysis studies agreed that CRRM reduced the risk of CBC in UBC patients with high familial/genetic risk (RR 0.04; 95%CI 0.02–0.09; P < 0.001) [13], especially those harboring a BRCA1/2 mutation (reduced by 91–93%; RR 0.07; 95%CI 0.04–0.15; P = 0.34) [14, 15].