In the pathological review of CRRM surgical specimens of BRCA1/2 mutation carriers, the risk of CBC lifted even higher because about 11% of occult cancer was observed despite the negative pre-surgical imaging findings [9]. A gradually increasing number of UBC patients carrying BRCA1/2 mutations are adopting CRRM, especially in those under the age of 45 considering these patients have more a more aggressive tumor biology and higher expectations for a longer survival [10–12]. Here, BRCA1 is linked to neoplasm.