Moreover, smoking (HR 4.205, 95% CI 1.645–10.752, p = 0.003), drinking (HR 0.299, 95% CI 0.095–0.943, p = 0.039), TNM stage (HR 0.253, 95% CI 0.105–0.607, p = 0.002), chemotherapy (HR 0.215, 95% CI 0.092–0.502, p < 0.001), MSI of MSH2-15 (HR 11.240, 95% CI 1.992–63.410, p = 0.006) and MSI of MCC-10 (HR 31.851, 95% CI 2.546–398.477, p = 0.007) were independent factor for PFS of CRC patients. Here, MSH2 is linked to colorectal carcinoma.