MSH2 and colorectal carcinoma: The results indicated that smoking (HR 3.975, 95% CI 1.565–10.079, p = 0.004), drinking (HR 0.281, 95% CI 0.090–0.885, p = 0.030), TNM stage (HR 0.246, 95% CI 0.102–0.595, p = 0.002), chemotherapy (HR 0.240, 95% CI 0.106–0.547, p = 0.001) and MSI of MSH2-15 (HR 7.701, 95% CI 1.039–57.030, p = 0.043) were independent factor for OS of CRC patients.