In stage II patients (n = 127), MSI in D17S250 (p = 0.006), pinch-5 (p = 0.001), MSH2-15 (p = 0.001), MCC-25 (p = 0.024), MCC-10 (p = 0.001), MCC-3 (p = 0.036), MCC-26 (p = 0.049), MGMT-10 (p = 0.04), and APC-6 (p = 0.049) loci exhibited poor outcomes in 5-year OS in CRC (Fig. 4C). The gene discussed is APC; the disease is colorectal carcinoma.