As shown in Fig. 7, except for the three genes (STK17B, JUNB, and PLEK), the expression levels of the other hub genes were up-regulated in the primary plasma cells from MM patients with t(4;14) compared to those without t(4;14), which was consistent with the markers at the late stage predictedby above mentioned bioinformatics analysis. The gene discussed is JUNB; the disease is Miyoshi myopathy.