Specifically, women of African descent, including African-American women in the United States [9] and Nigerian women, are more likely to be diagnosed with BC over-represented by the triple-negative (TN) subtypes, characterized by estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptor negativity [7, 8]. The gene discussed is PGR; the disease is breast cancer.