Of these LYZ encodes lysozyme, an antimicrobial peptide, CTSZ encodes cathepsin Z a lysosomal cysteine protease with multiple roles in host immune defense mechanisms, SREBF1 encodes a transcription factor involved in TLR4 signalling, while GRN encodes granulin, involved in TLR9 signalling, ANXA5 is involved in T-cell activation and ADARB1 encodes a deaminase enzyme with A-to-I RNA editing activity, which is important for the maintenance of cellular health but may also play a role in response to viral infection. The gene discussed is GRN; the disease is viral infectious disease.