et al. demonstrated that beta-lapachone induced rapid release of cytochrome C followed by activation of caspase-3 in apoptotic cell death in numerous human carcinoma cell lines of the breast cancer cell lines MCF-7, 21 MT, 21 NT, and 21 PT; AD 2780s (human ovary carcinoma); human colon adenocarcinoma cell lines SWI116, HT-29, and DLD; human prostate tumor cells PC-3, DU145, and LNCaP; and a human lung carcinoma cell line (G480). This evidence concerns the gene CASP3 and breast carcinoma.