With the 1D-WB analysis, all of the six proteins or fragments analyzed, S100A11, FABP1, HNRNPF, HNRNPH1/2, PKM and GSTP1, showed perturbation of the expression in the peripheral part of the tumor while a similar difference in the central part of the tumor was only detected with three of the proteins. This evidence concerns the gene PKM and neoplasm.