IGHE and inflammatory skin disease: In the control cases, results of double-immunofluorescence staining indicated the following: IgE-bearing IDECs and those with HDM antigens were hardly detected in the epidermis of the skin lesions of patients with non-eczematous inflammatory skin disorders and serum hyper-IgE, and in the epidermis of the skin lesions of patients with inflammatory skin disorders and spongiotic tissue within the epidermis, IDECs with HDM antigens were scarcely detected in the spongiotic epidermis in which IDECs without IgE had sufficiently infiltrated (Figure 3a–d; Table 2).