In the control cases with inflammatory skin disorders and spongiotic tissue within the epidermis, infiltrating double-positive cells with HDM antigens were scarcely found in the spongiotic epidermis by double-immunofluorescence staining for IgE and Der f1, IgE and Mite Extract antigens, CD206 and Der f1, and CD206 and Mite Extract antigens (Figure 3c,d: case 13). Here, IGHE is linked to inflammatory skin disease.