Nevertheless, even considering such limitations, we consider that the results of the present study demonstrated the crucial role of HDM allergens in the immunopathogenesis of eczematous dermatitis in IgE-allergic AD, in which the IgE-mediated delayed-type hypersensitivity reaction, together with IgE-bearing DCs (i.e., IDECs, LCs, and dermal inflammatory DCs), specific T cells, keratinocytes, and HDM antigens, may lead to spongiosis formation. This evidence concerns the gene IGHE and atopic eczema.