In the present immunohistopathological studies with double-immunofluorescence staining techniques for adult and elderly patients with IgE-allergic AD and HDM allergy, we confirmed that along with T-cell infiltration, IgE-bearing IDECs (CD11c+ and CD206+ cells) infiltrated and aggregated in the central area of the spongiotic epidermis in active lesions of chronic AD [25] in all of the AD patients [13]. Here, IGHE is linked to Alzheimer disease.