In the comparisons between the AD and control cases, the mean numbers of double-positive cells, i.e., IgE+ CD11c+ cells, IgE+ CD206+ cells, IgE+ Der f1+ cells, CD206+ Der f1+ cells, and IgE+ Mite Extract+ cells in the epidermis and IgE+ CD11c+ cells and IgE+ Der f1+ cells in the upper dermis, in the AD cases were significantly higher than those in each of the control groups. Here, IGHE is linked to Alzheimer disease.