Second, while Hu Y et al18 has reported that B7‐H3‐positive cases were more likely to have unfavorable karyotypes, no significant association between B7‐H3 and cytogenetic risk was observed by Guery T et al.19Lastly, Hu Y et al18 showed that B7‐H3 expression predicts worse outcome in acute leukemia (AL); in contrast, significantly better EFS and in trend a better OS in B7‐H3‐positive patients was observed by Guery T et al.19Our results on the prognostic relevance are in line with Hu Y et al18 showing that high B7‐H3 expression was associated worse clinical outcome. The gene discussed is CD276; the disease is acute leukemia.