CD4 and neoplasm: Notably, there was a significant increase in several immunosuppressive cells (i.e., macrophages, neutrophils, dendritic cells, Th17 cells, CD56dim natural killer cells, and monocytes) in patients with high B7‐H3,while cells executing anti‐tumor reactivity (i.e., activated CD4 T cells, effector memory CD4 T cell, and activated CD8 T cells) were generally under‐represented (Table 1).