Observational studies have consistently reported an association between Lp-PLA2 activity and risk of CHD, while showing no evidence of greater risk of ischaemic strokes with increased Lp-PLA2 activity (RR 1.08 [95% CI 0.97, 1.20]) [1, 2, 31]. The gene discussed is PLA2G7; the disease is ischemic stroke.