While the interaction p value for darapladib treatment by diabetes status in patients with high Lp-PLA2 (≤300.1 nmol min−1 ml−1) was not significant, a clear and consistent pattern is observed within and between the two study populations where an interaction was seen between enzyme activity and diabetes status (whether defined by type 2 diabetes status or HbA1c threshold). Here, PLA2G7 is linked to type 2 diabetes mellitus.