The recently established hPSC‐derived pancreatic organoids and beta cells92, 109 could serve as a brilliant platform in evaluating the role of ACE2 in regulating insulin secretion as well as on how ACE2 function in the beta cells is affected following SARS‐CoV‐2 and its implications on diabetes pathophysiology, thus warranting extensive studies. This evidence concerns the gene INS and diabetes mellitus.