TET2 and frontotemporal dementia: Our rare variant burden test (Supplementary Fig. 5) identified an enrichment for rare loss-of-function variants in GRN and indeed, with the second strongest enrichment after GRN (P = 2.2 × 10−21), we observed a nominally significant enrichment of variants in TET2 in the FTD cohort (P = 6.4 × 10−6).