The authors described an enrichment of rare variants in TET2 in the discovery set of a combined early-onset Alzheimer’s disease (EOAD) and FTD cohort, with an odds ratio (OR) of 28.9 (4.5–1200); P = 4.6 × 10−8 [33]. This evidence concerns the gene TET2 and early-onset autosomal dominant Alzheimer disease.