Tumor infiltrating CD4+ and CD8+ lymphocytes (TIL) were highly activated and CD8+ lymphocytes were particularly prone to IFN-γ production both in Bortezomib- and in DMSO-treated mice (frequency of CD4+CD69+: Bor 35.73 vs DMSO 33.37, p = 0.863; frequency of CD8+CD69+: Bor 36.80 vs DMSO 35.56, p = 0.867; frequency of CD4+IFN-γ+: Bor 5.66 vs DMSO 5.20, p = 0.839; frequency of CD8+IFN-γ+: Bor 13.45 vs DMSO 16.56, p = 0.686) (Supplementary Fig. S6). This evidence concerns the gene IFNG and neoplasm.