In addition, we explored for the first time the in vivo effects of Bortezomib in mice transplanted with murine adenocarcinoma salivary gland SALTO-5 cell line and analyzed tumor immune infiltrate (CD4+ and CD8+ T cells, B lymphocytes, macrophages, and Natural Killer (NK) cells), tumor vessels density and proteasome structural subunits (PSMA4, PSMD4, PSME1) and ubiquitin expression. The gene discussed is PSMD4; the disease is neoplasm.