The Nr2e3rd7/rd7 (rd7: retinal degeneration 7) mouse is a mouse model of the recessively inherited enhanced short-wavelength (S)-cone sensitivity syndrome (ESCS; MIM#208100), caused by bi-allelic pathogenic variants in NR2E3 (nuclear receptor class 2 family E member 3). Here, NR2E3 is linked to enhanced S-cone syndrome.