When the supernatant of emm type 32.2 was replaced with emm type 1.0 supernatant, the amount of SLO in the challenge inoculum was significantly reduced and 50% of the mice challenged were able to clear the infection, a delayed invasive phenotype was observed with mortality at 48 h instead of 24 h with emm type 32.2 and its original supernatant. The gene discussed is PIGG; the disease is infection.