Supplanting LDL-C by genetic associations with Apo-B, we observed suggestive but insufficiently precise, evidence of Apo-B mediating the CETP effect on CHD OR 0.60 per SD decrease in Apo-B (95% CI: 0.34–1.03), independent of HDL-C; Supplemental Fig. 4 and Table 8. The gene discussed is APOB; the disease is coronary artery disorder.