CETP and Alzheimer disease: While the pQTL CETP analysis did not show a convincing effect on AD (Fig. 3), the lipid weighted analyses provided directionally discordant results, observing a risk increasing AD effect when weighting by LDL-C (Supplemental Fig. 3), compared to a protective effect CETP mediated by increased HDL-C using an MVMR model accounting for LDL-C.