Lower instrumented CETP concentration was associated with lower risk of CHD (OR 0.95, 95% CI: 0.91–0.99), heart failure (HF) (OR 0.96, 95% CI: 0.93–0.98), CKD (OR 0.94, 95% CI: 0.91–0.97), and higher risk of AMD (OR 1.31, 95% CI: 1.22–1.39); Fig. 3 and Supplemental Table 6. This evidence concerns the gene CETP and heart failure.