PCSK9 and coronary artery disorder: The MVMR model for LDL-C and HDL-C (Fig. 6 and Supplemental Table 7) indicated that the CHD decreasing effects of PCSK9 were convincingly mediated by lower LDL-C (OR per SD decrease in LDL-C: 0.66, 95% CI: 0.58–0.75), for CETP we found evidence for HDL-C mediation instead (OR per SD increase in HDL-C: 0.85, 95% CI: 0.82–0.88).