Although it reported that the mammalian Hh pathway suppresses apoptosis via activating anti-apoptotic gene Bcl2 in tumor cells, no evidence supports the Hh pathway is able to activate Bcl2 orthologs in Drosophila. In addition, Buffy and Debcl, two counterparts of Bcl2 in Drosophila, do not play a key role in apoptosis. Here, BCL2 is linked to neoplasm.