Interleukin (IL)−33, a cytokine of the IL-1 family, was found to play an important role in the pathogenesis of allergic diseases, i.e., AD [1, 2], asthma [3], allergic rhinitis [4], urticaria [5], and allergic conjunctivitis [6], and targeting the IL-33 inflammatory axis has therapeutic potential in controlling AD [7]. This evidence concerns the gene IL33 and urticaria.