SEMA7A was first identified for its expression on lymphocytes [7], but has since been shown to exert diverse roles in neuronal development [8], cell differentiation [9–11], ECM deposition [12, 13], various components of the immune system [14–17], and pathologies including fibrosis [12, 18, 19] and cancer [16, 20–23]. This evidence concerns the gene SEMA7A and cancer.