Based on the published evidence [3] and on the data we show here, we conclude that ICD and immunogenic surrender differ in at least two respects: first, ICD is a form of regulated cell death, whereas in immunogenic surrender the cells do not die in a cell-autonomous way; second, extracellular HMGB1 is released by tumor cells in both mechanisms, but it is necessary for ICD and not for immunogenic surrender. The gene discussed is HMGB1; the disease is neoplasm.