In addition, infection with rSARS-CoV-2/Venus-2A and rSARS-CoV-2/Δ7a-Venus resulted in comparable viral titers to those observed in K18 hACE2 transgenic mice infected with rASRS-CoV-2/WT in all organs at all times pi (Fig. 3E), suggesting that the undetectable Venus expression in the lungs of K18 hACE2 mice infected with rSARS-CoV-2/Δ7a-Venus is unlikely due to lower levels of viral replication in vivo. The gene discussed is KRT18; the disease is infection.