Investigating high levels of fibroblast TGFBI in pancreatic cancer tissues, Goehrig and colleagues found that this molecule interacted directly with T cells and macrophages and that neutralising anti-TGFBI antibodies reduced tumor growth, enhanced CD8+ T-cell activation, and polarized macrophages to an M1 state. The gene discussed is TGFBI; the disease is familial pancreatic carcinoma.