FLT3 and acute myeloid leukemia: Six of these variants are classic AML driver and recurrent hotspot mutations whereas variants such as FLT3 p.T526M (Patient 4), ATM c.497-1G>T (Patient 6), CEBPA p.Q346fs*10 (Patient 6) and CEBPA p.V343fs*11 (Patient 6) were not previously reported in AML (Table 1).