MAPT and Alzheimer disease: Experimental studies have described a TUSS-driven decrease of p-Tau levels in the hippocampus of three different mutant-Tau transgenic mouse models (i.e., K3, rTg4510, and 3xTg-AD mice) after single [45, 58] or multiple US sonications (2.4 min once a week, 15 weeks period) [66].