On the other hand, two studies have reported a reduction in gliosis ( by assessment of glial fibrillary acidic protein [GFAP] [56] and ionized calcium-binding adaptor molecule 1 [Iba1] [56, 57]) in the brains of AD mouse models, either after a single TUSS session of 1 min (marked effect in the hippocampus and entorhinal cortex of 5xFAD mice) [56], or after a repetitive TUSS treatment (3 sessions/20 min each on alternate days, the first week of each month for three months) [57]. The gene discussed is AIF1; the disease is Alzheimer disease.