MAPT and Alzheimer disease: Among the most promising ones, the mechanical wave-based modalities acting at different vibration modes have been associated with improvement of AD neuropathology beyond the reduction of Aβ and Tau accumulation, affecting various pathological parameters involved in AD such as chronic neuroinflammation, synaptic loss, and neuronal atrophy; importantly, these alterations are also accompanied by an attenuation of cognitive and other behavioral deficits.