Although inflammation such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels, cardiotoxic medication, and RA disease itself have been thought to be the risk factors for the development of diastolic impairment, the precise mechanisms involved in increased cardiovascular disease (CVD) risk are various and remain elusive [11]. The gene discussed is TNF; the disease is cardiovascular disorder.