CSF NLK levels correlated with CSF t-tau levels (Nijmegen aMCI/AD patients and controls: rSPc = 0.65, p < 0.0001; Barcelona aMCI/AD patients and controls rSPc = 0.60, p < 0.0001) and CSF p-tau levels (Nijmegen aMCI/AD patients and controls: rSPc = 0.65, p < 0.0001; Barcelona aMCI/AD patients and controls: rSPc = 0.58, p < 0.0001). The gene discussed is NLK; the disease is Alzheimer disease.