To illuminate the mechanism of the suppressive roles of CMTM3 in chordomas, we detected the expression of the epithelial specific junction protein E-cadherin and the mesenchymal proteins N-cadherin and Vimentin in CMTM3-overexpressed JHC7 and U-CH1 cells and CMTM3 silenced MUG-Chor1 and U-CH1 cells. Here, CMTM3 is linked to chordoma.