IGF1 and hyperinsulinism: The DASH diet also advocates lower intakes of sugar-sweetened beverages; although the relationship between such beverages and CRC and CRA has not been fully confirmed, hyperinsulinemia and increased insulin growth factor-1 (IGF-1) consequential to consumption of these drinks can effect on carcinogenesis and conversion of adenomas to malignancies through crucial pathways, such as mitogen-activated protein kinase (MAPK) pathway and phosphoinositide 3-kinase (PI3K) pathway [44–46].