GSK3B and colorectal cancer: NT has been implicated in the regulation of the WNT/β-catenin pathway in glioblastoma and hepatocellular carcinoma and is a downstream target of the WNT pathway in neuroendocrine tumor cells.28, 29, 30 In colorectal cancer (CRC) cells, NT mediates phosphorylation and inhibition of glycogen synthase kinase 3 beta (GSK3β), a repressor of WNT/β-catenin signaling.31