PSEN1 and Mental deterioration: Lastly, our findings may also be explained by the attention and frontal/executive demands of this task (with the localisation measure being particularly sensitive due to its continuous nature), rather than the visuo-spatial or memory aspects per se as well as differences in life-course factors (e.g. socio-economic status and occupation type), some of which have been shown to impact the onset and rate of cognitive decline in individuals with certain FAD mutations (e.g. (Aguirre-Acevedo et al., 2016)).