Even after adjusting for age, gender, BMI, hypertension, heart failure, malignancy, etiologies of ICU admission (including sepsis, pneumonia, acute heart failure, massive bleeding), APACHE II scores, SOFA scores, ventilator usage, inotrope/ vasopressor usage, MAP, septic shock, hemoglobin, initial eGFR, and lactate concentration, patients in the median (adjusted HR 2.56, 95% CI 1.44–4.55, p = 0.001; S1 Table) and in the high Gal-1 tertiles (adjusted HR 3.23, 95% CI 1.82–5.73, p < 0.001) remained independently associated with greater 90-day mortality. Here, LGALS1 is linked to Sepsis.