Previous studies have shown that type III collagen (COL3A1), Fibronectin (FN) 1, COL5A1, fibrillin 1 (FBN1), collagen type VI alpha 1 (COL6A1) and Thrombospondin-2 (THBS2) were significantly associated with a worse overall survival of BC patients [45]. The gene discussed is THBS2; the disease is breast cancer.