We found a higher risk of new-onset AF with vWF:Ag levels in the highest quartile as compared to the lowest quartile [HR (95% CI): 1.37 (1.11–1.70)], and for ADAMTS13 levels in the lowest quartile, as compared to the highest [HR (95% CI): 1.51 (1.23–1.86)] in univariable models. This evidence concerns the gene RENBP and atrial fibrillation.