Sex-stratified analyses showed a larger risk for AF with vWF:Ag levels < 1.61 IU/mL and ADAMTS13 activity ≤ 80.31% [HR (95% CI): 1.55 (1.22–1.97)] in men in univariable analysis, but not in women. The gene discussed is RENBP; the disease is atrial fibrillation.