NEFL and dementia: There was no effect of FRM-0334 on concentrations of plasma PGRN (4.3 pg/mL per day change after treatment; 95% CI, −10.1 to 18.8; P = .56), CSF PGRN (0.42 pg/mL per day; 95% CI, −0.12 to 0.95; P = .13) (Figure 1A and B), or exploratory PD outcomes (CSF NfL, CSF Aβ1-42, CSF p-tau181, and CSF t-tau, CDR plus NACC FTLD sum of boxes, Frontotemporal Dementia Rating Scale, and bifrontal FDG-SUVR) after 28 days of treatment (Figure 1C; eTable 2 in Supplement 2).