In this comparison of an LA regimen alone compared with an LA plus SA insulin regimen using a Super Learner strategy with adjustment for patient demographic details, smoking, clinical values, comorbid conditions, concomitant medications, neighborhood-level socioeconomic variables, and clinician and site characteristics, the LA plus SA regimen was associated with increased mortality (HR, 1.27; 95% CI, 1.05-1.49) and lower risk of myocardial infarction (HR, 0.89; 95% CI, 0.81-0.97) compared with the LA regimen alone. Here, INS is linked to myocardial infarction.