Expect for infliximab and steroids, the rest of the treatments were unavailable in Syria,[4] and the surgery is considered the last therapeutic option in the treatment of UC flares.[6] Golimumab is a new fully human, monoclonal anti-TNF indicated for the treatment of adults with rheumatoid arthritis,[7–11] psoriatic arthritis,[12,13] ankylosing spondylitis,[14,15] and ulcerative colitis.[16,17] In children, golimumab had been used exclusively for rheumatologic diseases.[18]. This evidence concerns the gene TNF and ulcerative colitis.