CYP2D6 and cancer: Our literature search found other instances of quantitative measures of gene activity combined with routine data, including the 21-gene Recurrence Score, which measures the activity of 21 genes (16 cancer-related and 5 reference) for patients with breast cancer [33] and the enzyme activity score for the CYP2D6 (cytochrome P450 family 2 subfamily D member 6) gene, which codes for an important drug-metabolizing enzyme, and is highly polymorphic in humans [34].