Flavoenzyme derangement, ATP shortage and redox balance impairment, accompanied by infertility and alteration of locomotion behaviour, could make flad‐1 silenced C. elegans animals a model system for studying human neuromuscular pathologies with alteration in flavin homeostasis/flavoenzyme biogenesis, as suggested in the past,21, 37 and further confirmed by experiments presented in this article. This evidence concerns the gene FLAD1 and Infertility.