The mammalian version of PP2A plays a key role in the pathogenesis of various human diseases, ranging from cancer and neurodegenerative diseases to immunoregulatory dysfunctions (Perrotti & Neviani, 2008; Sontag & Sontag, 2014; Apostolidis et al, 2016; Meeusen & Janssens, 2018; Westermarck, 2018; Bao et al, 2020). Here, PTPA is linked to cancer.